- Cy Young pitched for both the Cleveland Spiders (NL) and the Cleveland Naps (AL) at League Park, a 12-3 win over the Reds.
- The Cleveland Indians (Blues) played their first Major League game on April 29, 1901. Their opponent was Milwaukee and they defeated the Brewers 4-3 at League Park.
- September 18, 1908 - At Cleveland's League Park, Bob Rhoads tosses a no-hitter against beating the Red Sox, 2-1. The Indian hurler out duels Frank Arellanes, who is the only Mexican-American playing in the majors.
- October 2, 1908: Addie Joss tosses a perfect game against the Chicago White Sox.
- July 19, 1915: Wahington Senators steal a record eight bases in one inning.
- September 27, 1914: Nap Lajoie gets hit number 3,000.
- Site of the 1920 World Series
- the first grand slam in World Series history
- first unassisted triple play in baseball history (1920 World Series).
- Indians second baseman Bill Wambsganss made the only unassisted triple play in World Series history here on October 10, 1920 in game 5 against the Brooklyn Robins (Dodgers). In the same game Elmer Smith hit the first grand-slam and Kim Bagby became the first pitcher to hit a home run in World Series history.*
- On July 7, 1923, the Cleveland Indians set an American League record by scoring 27 runs against the Boston Red Sox at League Park. The Indians win, 27-3, as they score at least one run in each inning. The Sox’ Lefty O’Doul surrenders 16 runs, 11 hits, and eight walks in three innings of work. O’Doul will later give up pitching and become an outfielder.
- July 22, 1923: Walter Johnson gets his 3,000th strike out.
- May 17, 1925: Tris Speaker gets hit number 3,000.
- Ty Cobb made his record 54th career steal of home on June 15, 1928. This record is unbroken.
- 500th Home Run by Babe Ruth on August 11, 1929
- Cleveland Indians pitcher Bob Feller's first game (1936)
- Used only for the Indians weekday games from 1934 to 1946.
- July 10, 1932: Cleveland's John Burnett collects a single-game record nine hits in 18 innings. The Indians get 33 hits in the game, and the Athletics have 25 of their own, setting the one and two team records.
- Joe DiMaggio's 56th and final hit of his famed hitting streak occurred at League Park.
- The first one-million season was in 1946, when 1,057,289 fans attended games at League Park (II) and Cleveland Stadium.
- Ted Williams hit his only inside the park home run on September 13, 1946 at League Park.
- 1945 Negro League Champion
- 1947 Negro American League Pennant